Thalidomide

Thalidomide was a drug that was prescribed to pregnant women in the recently 1950s and early 1960s to help combat dawn sickness. It effectively reduced the symptoms of morning sickness in those women, notwithstanding at a horrible cost. Many of the children born from women who took Thalidomide dudoughnut maternalism were born with give defects and were c each(prenominal)ed Thalidomide babies. In reference to the stereochemistry of Thalidomide, in that respect is barely one chiral carbon, and thus just cardinal isomers. Thalidomide exists in two stereoisomers, S-thalidomide, which is a sedative that calms nervousness, and R-thalidomide, which was found to be a teratogen that causes birth defects. The carbon atom from the carbon-nitrogen bond connecting the two main ring structures is chiral, as shown on the attached bonus paper. The R-thalidomide isomer is the one that causes all the problems with birth defects, so one might think that if the S-thalidomide isomer was disposed to patients instead, there wouldnt have been such a dread(a) problem. That, however, isnt the case. Humans convert the S-thalidomide into R-thalidomide once in the body, so it really doesnt matter which enantiomer is taken, it would have toxic effects to the babies of the pregnant women anyway.



Although the use of Thalidomide for morning sickness and its libellous effects to the babies has been called one of the biggest medical tragedies of modern times, there was some good to come from finding the bad results. The Thalidomide calamity led to much stricter testing being required for drugs and pesticides before they can be licensed. In addition, it has been found to be a viable treatment for many medical conditions including multiple myeloma in people who have been recently found to have this disease. Its also used to treat and prevent skin symptoms of erythema nodosum leprosum(ENL or leprosy).If you want to get a full essay, order it on our website: Ordercustompaper.com



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